2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128851E
    Disulfide-CoA octalithium 98%
    Disulfide-CoA (Disulfide-coenzyme A) octalithium is a coenzyme A derivative.
    Disulfide-CoA octalithium
  • HY-128854S
    Dimethyl biphenyl-4,4'-dicarboxylate-d8 1219803-50-5 98%
    Dimethyl biphenyl-4,4'-dicarboxylate-d8 is the deuterium labeled Dimethyl biphenyl-4,4'-dicarboxylate. Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotectant obtained from Schizandra fructus and may induce a signal transduction similar to that associated with IFN.
    Dimethyl biphenyl-4,4'-dicarboxylate-d8
  • HY-128895A
    KL1333 hydrochloride 1800406-26-1 98%
    KL1333 hydrochloride is an orally active NAD+ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures.
    KL1333 hydrochloride
  • HY-129046J
    RNase B Glycoprotein Standard 98%
    RNase B Glycoprotein Standard is a substrate containing PNGase F and can be used to determine PNGase F activity. RNase B Glycoprotein Standard can be used as a glycoprotein standard.
    RNase B Glycoprotein Standard
  • HY-129047H
    Trypsin, Rat
    Trypsin, Rat (EC 3.4.21.4) is a serine protease belonging to the PA superfamily. It is present in the digestive systems of many vertebrates and hydrolyzes proteins. Trypsin, Rat (EC 3.4.21.4) primarily cleaves peptide chains at the carboxyl terminus of lysine or arginine, but cleavage does not occur when lysine or arginine is followed by proline.
    Trypsin, Rat
  • HY-129064C
    Superoxide Dismutase, Bovine
    Superoxide Dismutase, Bovine (EC 1.15.1.1) catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Superoxide Dismutase plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Superoxide Dismutase competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby Superoxide Dismutase promotes the activity of NO.
    Superoxide Dismutase, Bovine
  • HY-129064D
    Superoxide Dismutase, Roxburgh
    Superoxide Dismutase, Roxburgh (EC 1.15.1.1) catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Superoxide Dismutase plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Superoxide Dismutase competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby Superoxide Dismutase promotes the activity of NO.
    Superoxide Dismutase, Roxburgh
  • HY-129064E
    Superoxide Dismutase, Escherichia coli
    Superoxide Dismutase, Escherichia coli (EC 1.15.1.1), catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen. Superoxide dismutase (SOD) plays a crucial role in cellular defense against the toxic effects of oxygen free radicals. Superoxide dismutase competes with nitric oxide (NO) for superoxide anions (which react with NO to form peroxynitrite), thereby promoting NO activity.
    Superoxide Dismutase, Escherichia coli
  • HY-129064H
    Superoxide Dismutase, Horseradish
    Superoxide dismutase, Horseradish (EC 1.15.1.1), catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen. Superoxide dismutase (SOD) plays a crucial role in cellular defense against the toxic effects of oxygen free radicals. Superoxide dismutase competes with nitric oxide (NO) for superoxide anions (which react with NO to form peroxynitrite), thereby promoting NO activity.
    Superoxide Dismutase, Horseradish
  • HY-129143R
    Delphinidin-3-sambubioside chloride (Standard) 53158-73-9
    Delphinidin-3-sambubioside (chloride) (Standard) is the analytical standard of Delphinidin-3-sambubioside (chloride). This product is intended for research and analytical applications. Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
    Delphinidin-3-sambubioside chloride (Standard)
  • HY-129380R
    Fructosyl-lysine (Standard) 21291-40-7
    Diethylene glycol (Standard) is the analytical standard of Diethylene glycol. This product is intended for research and analytical applications. 2,2'-Oxybis(ethan-1-ol) (DIETHYLENE GLYCOL) has excellent solubility and reactivity in certain chemical reactions and can help accelerate the activation of certain reactants. In addition, it is widely used in the production process of pigments, resins and other chemicals. Although the compound has no direct medical application, it has wide applications in chemical research and industrial production.
    Fructosyl-lysine (Standard)
  • HY-129566R
    Withanolide B (Standard) 56973-41-2
    Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
    Withanolide B (Standard)
  • HY-129736A
    P32/98 136259-20-6 98%
    P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.
    P32/98
  • HY-130237R
    Cinnamtannin B-1 (Standard) 88082-60-4
    Cinnamtannin B-1 (Standard) is the analytical standard of Cinnamtannin B-1. This product is intended for research and analytical applications. Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active.
    Cinnamtannin B-1 (Standard)
  • HY-130245A
    (R,R)-PCSK9 degrader 1 2216703-12-5 98%
    (R,R)-PCSK9 degrader 1 is the isomer of PCSK9 degrader 1 (HY-130245). PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor.
    (R,R)-PCSK9 degrader 1
  • HY-130310B
    (±)11-HEDE 5598-37-8 98%
    (±)11-HEDE is a racemic mixture of the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE. 11-HEDE is formed from eicosadienoic acid by cyclooxygenase (COX) and in macrophages.
    (±)11-HEDE
  • HY-130569A
    7-Hydroxymethotrexate sodium
    7-Hydroxymethotrexate sodium is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxymethotrexate sodium
  • HY-131103R
    Phenylethanolamine A (Standard) 1346746-81-3
    Phenylethanolamine A (Standard) is the analytical standard of Phenylethanolamine A. This product is intended for research and analytical applications. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A (Standard)
  • HY-131103S
    Phenylethanolamine A-d3 2507994-61-6
    Phenylethanolamine A-d3 is a deuterium labeled Phenylethanolamine A. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.
    Phenylethanolamine A-d3
  • HY-131105R
    Cimbuterol (Standard) 54239-39-3
    Cimbuterol (Standard) is the analytical standard of Cimbuterol (HY-131105). This product is intended for research and analytical applications. Cimbuterol is a β-adrenergic agonist. β-adrenergic agonists act as bronchodilators and tocolytics. β-adrenergic agonists promote growth.
    Cimbuterol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity